![]() Estradiol is uncommonly recommended by most veterinarians for use for mismating due to possible side effects and safer alternative drugs.Combination birth control pills are a reliable form of contraception that's easily reversed.In cats, the usual dose for mismating is 0.0625 to 0.125 mg per pound (0.125-0.25 mg/kg) intramuscularly.In dogs, the usual dose for mismating is 0.01 to 0.02 mg per pound (0.02 – 0.04 mg/kg) given intramuscularly.Even if your pet feels better, the entire treatment plan should be completed to prevent relapse. Be certain to complete the prescription unless specifically directed by your veterinarian. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects.Doses of estradiol vary widely depending on the reason for prescribing.Medication should never be administered without first consulting your veterinarian.The injectable forms of estradiol cypionate include 2 and 4 mg/mL concentrations.ĭosing Information of Estradiol for Dogs and Cats.Estradiol is available in 0.5 mg, 1 mg, 1.5 mg, or 2 mg micronized estradiol tablets.Loss of seizure control may occur when estrogens are administered to hydantoin-treated epileptics.ketoconazole and macrolide antibiotics) decrease the plasma levels and effectiveness of estrogens. barbiturates) decrease plasma levels and thus the effectiveness of estrogens. Estrogens also increase the pharmacologic and toxologic effects of corticosteroids and increase thyroid hormone requirements in hypothyroid patients.They may also alter the pharmacological effect of tricyclic antidepressants, increasing their toxicity.Estrogens in general may reduce the effects of anticoagulants.Estradiol enhances absorptive functions of the dog proximal small intestine and can affect pharmacokinetics of some orally administered drugs.Consult with your veterinarian to determine if other drugs your pet is receiving could interact with estradiol. Estradiol may interact with other medications.Overdose of estrogen has been reported to cause anemia and thrombocytopenia.Estrogens are considered toxic to bone marrow in small animals and may lead to blood dyscrasias.In males, estradiol can cause feminization.Use of estradiol to prevent embryo implantation is subsequently associated with a high incidence of cystic endometrial hyperplasia and pyometra.Estradiol should not be used in animals that appear hypersensitive to it or any components of the medication.Hormone replacement therapy for spayed female dogs, particularly those with urinary incontinence (although another drug called DES is used more commonly).Palliative treatment for benign anal tumors in elderly male dogs.To prevent implantation of the fertilized ova in mismatched bitches.Veterinary formulations: ECP® (Pharmacia) and generic estradiol cypionate.Human formulations: Estrace® (Warner Chilcott), Gynodiol® (Fielding), and generic estradiol.This drug is registered for use in humans and cattle.Estradiol is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.This drug is not approved for use in dogs and cats by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug.In cats, estrogen metabolites are excreted preferentially in feces (in equal amounts of unconjugated estradiol and conjugates). In most species, it is metabolized by the liver and the metabolites are excreted in both urine and bile.Exogenous estradiol is distributed throughout the body, accumulating in fat.It is responsible for the development of secondary sexual characteristics increases calcium deposition in bones and accelerates epiphyseal closure has a slight anabolic effect and increases retention of sodium and water. Estradiol is the most active endogenous estrogen.It is also used by injection to prevent embryo implantation in dogs and cats if given within 72 hours of mating.Estradiol cypionate, better known as Estrace® or ECP®, is a semisynthetic estrogenic hormone used as a replacement therapy in conditions of inadequate estrogen production for dogs and cats.Overview of Estradiol for Canines and Felines ![]()
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